Alternative splicing of the glutamate transporter EAAT2 (GLT-1)

被引：51

作者：

Meyer, T ^{[1
]}

Münch, C ^{[1
]}

Knappenberger, B ^{[1
]}

Liebau, S ^{[1
]}

Völkel, H ^{[1
]}

Ludolph, AC ^{[1
]}

机构：

[1] Univ Ulm, Dept Neurol, D-89081 Ulm, Germany

来源：

NEUROSCIENCE LETTERS | 1998年 / 241卷 / 01期

关键词：

excitatory amino acids; glutamate; transporter; alternative splicing; genetics neurodegeneration;

D O I：

10.1016/S0304-3940(97)00973-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The human glutamate transporter EAAT2 (GLT-1) is of major importance for synaptic glutamate reuptake, and reportedly, a candidate gene for neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer's disease and epilepsy, Here we report the polymerase chain reaction (PCR) cloning of two novel EAAT2 transcripts, named EAAT2-C1 and EAAT2-C2, which originate from alternative splicing of the human EAAT2 gene, EAAT2-C1 results from skipping of the protein coding exon eight, In contrast, EAAT2-C2 is characterized by usage of internal splice sites in the exons five and six, The splicing events lead to a deletion of 45 and 107 amino acids, respectively, located in the C-terminal and central part of the putative protein. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：68 / 70

页数：3

共 17 条

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