Cancer and Inflammation: Implications for Pharmacology and Therapeutics

被引：191

作者：

Balkwill, F. ^{[1
]}

Mantovani, A. ^{[2
]}

机构：

[1] Queen Mary Univ London, Barts & London Sch Med & Dent, Inst Canc, Ctr Canc & Inflammat, London, England

[2] Univ Milan, Ist Clin Humanitas, Milan, Italy

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2010年 / 87卷 / 04期

关键词：

NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; OVARIAN-CANCER; RHEUMATOID-ARTHRITIS; CXCR4; ANTAGONIST; PROGENITOR CELLS; PROSTATE-CANCER; TUMOR-GROWTH; INTERLEUKIN-6; CYTOKINE;

D O I：

10.1038/clpt.2009.312

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Smoldering, nonresolving inflammation is a component of the tumor microenvironment. The linkage between inflammation and cancer, first perceived in the nineteenth century, is now part of an accepted paradigm of carcinogenesis.

引用

页码：401 / 406

页数：6

共 52 条

[21] Tumor necrosis factor α as a new target for renal cell carcinoma:: Two sequential phase II trials of infliximab at standard and high dose
Harrison, Michelle L.
Obermueller, Eva
Maisey, Nick R.
Hoare, Susan
Edmonds, Kim
Li, Ningfeng F.
Chao, David
Hall, Kate
Lee, Chooi
Timotheadou, Eleni
Charles, Kellie
Ahern, Roger
King, D. Mike
Eisen, Tim
Corringham, Robert
DeWitte, Mark
Balkwill, Frances
Gore, Martin
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (29) : 4542 - 4549
[22] Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rγnull mouse model
Ito, Asahi
Ishida, Takashi
Yano, Hiroki
Inagaki, Atsushi
Suzuki, Susumu
Sato, Fumihiko
Takino, Hisashi
Mori, Fumiko
Ri, Masaki
Kusumoto, Shigeru
Komatsu, Hirokazu
Iida, Shinsuke
Inagaki, Hiroshi
Ueda, Ryuzo
[J]. CANCER IMMUNOLOGY IMMUNOTHERAPY, 2009, 58 (08) : 1195 - 1206
[23] Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases
Kim, Su Young
Lee, Chih Hung
Midura, Brieanne V.
Yeung, Choh
Mendoza, Arnulfo
Hong, Sung Hyeok
Ren, Ling
Wong, Donald
Korz, Walter
Merzouk, Ahmed
Salari, Hassan
Zhang, Hong
Hwang, Sam T.
Khanna, Chand
Helman, Lee J.
[J]. CLINICAL & EXPERIMENTAL METASTASIS, 2008, 25 (03) : 201 - 211
[24] Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis
Kim, Sunhwa
Takahashi, Hiroyuki
Lin, Wan-Wan
Descargues, Pascal
Grivennikov, Sergei
Kim, Youngjun
Luo, Jun-Li
Karin, Michael
[J]. NATURE, 2009, 457 (7225) : 102 - U108
[25] Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma
Komori, Junji
Marusawa, Hiroyuki
Machimoto, Takafumi
Endo, Yoko
Kinoshita, Kazuo
Kou, Tadayuki
Haga, Hironori
Ikai, Iwao
Uemoto, Shinji
Chiba, Tsutomu
[J]. HEPATOLOGY, 2008, 47 (03) : 888 - 896
[26] The inflammatory cytokine tumor necrosis factor-α generates an autocrine tumor-promoting network in epithelial ovarian cancer cells
Kulbe, Hagen
Thompson, Richard
Wilson, Julia L.
Robinson, Stephen
Hagemann, Thorsten
Fatah, Rewas
Gould, David
Ayhan, Ayse
Balkwill, Frances
[J]. CANCER RESEARCH, 2007, 67 (02) : 585 - 592
[27] IL-23 promotes tumour incidence and growth
Langowski, John L.
Zhang, Xueqing
Wu, Lingling
Mattson, Jeanine D.
Chen, Taiying
Smith, Kathy
Basham, Beth
McClanahan, Terrill
Kastelein, Robert A.
Oft, Martin
[J]. NATURE, 2006, 442 (7101) : 461 - 465
[28] Low Levels of Tumor Necrosis Factor α increase Tumor Growth by Inducing an Endothelial Phenotype of Monocytes Recruited to the Tumor Site
Li, Bin
Vincent, Alicia
Cates, Justin
Brantley-Sieders, Dana M.
Polk, D. Brent
Young, Pampee P.
[J]. CANCER RESEARCH, 2009, 69 (01) : 338 - 348
[29] Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist
Liles, WC
Broxmeyer, HE
Rodger, E
Wood, B
Hübel, K
Cooper, S
Hangoc, G
Bridger, GJ
Henson, GW
Calandra, G
Dale, DC
[J]. BLOOD, 2003, 102 (08) : 2728 - 2730
[30] Induction of a Chronic Disease State in Patients With Smoldering or Indolent Multiple Myeloma by Targeting Interleukin 1β-Induced Interleukin 6 Production and the Myeloma Proliferative Component
Lust, John A.
Lacy, Martha Q.
Zeldenrust, Steven R.
Dispenzieri, Angela
Gertz, Morie A.
Witzig, Thomas E.
Kumar, Shaji
Hayman, Suzanne R.
Russell, Stephen J.
Buadi, Francis K.
Geyer, Susan M.
Campbell, Megan E.
Kyle, Robert A.
Rajkumar, S. Vincent
Greipp, Philip R.
Kline, Michael P.
Xiong, Yuning
Moon-Tasson, Laurie L.
Donovan, Kathleen A.
[J]. MAYO CLINIC PROCEEDINGS, 2009, 84 (02) : 114 - 122

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