Improvement of the antitumor activity of black currant polysaccharide by an enzymatic treatment

被引：27

作者：

Takata, Ryoji ^{[1
]}

Yanai, Takaaki ^{[1
]}

Yamamoto, Relko ^{[1
]}

Konno, Tomonori ^{[1
]}

机构：

[1] Mercian Corp, Prod Dev Res Lab, Fujisawa, Kanagawa 2510057, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2007年 / 71卷 / 05期

关键词：

black currant; polysaccharides; beta-galactosidase; macrophage; antitumor;

D O I：

10.1271/bbb.60725

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A polysaccharide-rich substance isolated from black currant, named cassis polysaccharide (CAPS), was partially digested with fl-galactosidase from Aspergillus oryzae and its immunostimulatory activity was investigated. The in vitro cytokine-inducing effect of CAPS on RAW264 cells was gradually decreased along with lowering of the average MW of CAPS. In vivo, partially digested CAPS with a mean MW of approximately 20,000 showed the most potent antitumor activity against Ehrlich carcinoma in mice.

引用

页码：1342 / 1344

页数：3

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