DNA methylation in health and disease

被引：834

作者：

Robertson, KD

Wolffe, AP

机构：

[1] Sangamo Biosci, Point Richmond Tech Ctr, Richmond, CA 94804 USA

[2] NCI, Epigenet Gene Regulat & Canc Sect, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS GENETICS | 2000年 / 1卷 / 01期

关键词：

D O I：

10.1038/35049533

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

DNA methylation has recently moved to centre stage in the aetiology of human neurodevelopmental syndromes such as the fragile X, ICF and Rett syndromes. These diseases result from the misregulation of genes that occurs with the toss of appropriate epigenetic controls during neuronal development. Recent advances have connected DNA methylation to chromatin-remodeling enzymes, and understanding this link will be central to the design of new therapeutic tools.

引用

页码：11 / 19

页数：9

共 102 条

[1] Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
Amir, RE
Van den Veyver, IB
Wan, M
Tran, CQ
Francke, U
Zoghbi, HY
[J]. NATURE GENETICS, 1999, 23 (02) : 185 - 188
[2] NUMBER OF CPG ISLANDS AND GENES IN HUMAN AND MOUSE
ANTEQUERA, F
BIRD, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) : 11995 - 11999
[3] Effects of Rett syndrome mutations of the methyl-CpG binding domain of the transcriptional repressor MeCP2 on selectivity for association with methylated DNA
Ballestar, E
Yusufzai, TM
Wolffe, AP
[J]. BIOCHEMISTRY, 2000, 39 (24) : 7100 - 7106
[4] Baylin SB, 1998, ADV CANCER RES, V72, P141
[5] LOSS OF METHYLATION ACTIVATES XIST IN SOMATIC BUT NOT IN EMBRYONIC-CELLS
BEARD, C
LI, E
JAENISCH, R
[J]. GENES & DEVELOPMENT, 1995, 9 (19) : 2325 - 2334
[6] CLONING AND SEQUENCING OF A CDNA-ENCODING DNA METHYLTRANSFERASE OF MOUSE CELLS - THE CARBOXYL-TERMINAL DOMAIN OF THE MAMMALIAN ENZYMES IS RELATED TO BACTERIAL RESTRICTION METHYLTRANSFERASES
BESTOR, T
LAUDANO, A
MATTALIANO, R
INGRAM, V
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1988, 203 (04) : 971 - 983
[7] TRANSCRIPTIONAL NOISE AND THE EVOLUTION OF GENE NUMBER
BIRD, A
TWEEDIE, S
[J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1995, 349 (1329) : 249 - 253
[8] BIRD A, 1985, CELL, V40, P91, DOI 10.1016/0092-8674(85)90312-5
[9] GENE NUMBER, NOISE-REDUCTION AND BIOLOGICAL COMPLEXITY
BIRD, AP
[J]. TRENDS IN GENETICS, 1995, 11 (03) : 94 - 100
[10] CHROMATIN STRUCTURE IS REQUIRED TO BLOCK TRANSCRIPTION OF THE METHYLATED HERPES-SIMPLEX VIRUS THYMIDINE KINASE GENE
BUSCHHAUSEN, G
WITTIG, B
GRAESSMANN, M
GRAESSMANN, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (05) : 1177 - 1181

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