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DNA methylation in health and disease

被引：834
作者：
Robertson, KD
Wolffe, AP
机构：
[1] Sangamo Biosci, Point Richmond Tech Ctr, Richmond, CA 94804 USA
[2] NCI, Epigenet Gene Regulat & Canc Sect, NIH, Bethesda, MD 20892 USA
来源：
NATURE REVIEWS GENETICS | 2000年 / 1卷 / 01期
关键词：
D O I：
10.1038/35049533
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
DNA methylation has recently moved to centre stage in the aetiology of human neurodevelopmental syndromes such as the fragile X, ICF and Rett syndromes. These diseases result from the misregulation of genes that occurs with the toss of appropriate epigenetic controls during neuronal development. Recent advances have connected DNA methylation to chromatin-remodeling enzymes, and understanding this link will be central to the design of new therapeutic tools.
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页码：11 / 19
页数：9
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