Metabolic imaging of untreated prostate cancer by positron emission tomography with (18)fluorine-labeled deoxyglucose

被引:225
作者
Effert, PJ [1 ]
Bares, R [1 ]
Handt, S [1 ]
Wolff, JM [1 ]
Bull, U [1 ]
Jakse, G [1 ]
机构
[1] RHEIN WESTFAL TH AACHEN,DEPT MED NUCL & PATHOL,W-5100 AACHEN,GERMANY
关键词
prostatic neoplasms; tomography; emission-computed; fluorine radioisotopes; deoxyglucose;
D O I
10.1016/S0022-5347(01)66366-3
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose: We evaluated positron emission tomography (PET) with (18)fluorine (F-18)-labeled deoxyglucose for metabolic grading of untreated primary prostate cancer, and differentiation of benign and malignant prostatic disease. Materials and Methods: A total of 48 patients with untreated prostate cancer of different stages and 16 with histologically confirmed benign prostatic hyperplasia (BPH) underwent static PET after intravenous injection of 150 to 300 MBq. F-18-deoxyglucose. F-18-deoxyglucose accumulation was quantitated by calculating differential uptake ratios and prostate-to-skeletal muscle ratios. Results: Low F-18-deoxyglucose uptake was noted in the majority of primary tumors (81%). F-18-deoxyglucose accumulation did not correlate with increasing tumor grade or stage, There was a significant overlap in uptake values in BPH and malignant prostatic disease. A trend towards statistical significance was noted with lower prostate-to-skeletal muscle ratios in patients with BPH (p <0.07). Increased F-18-deoxyglucose accumulation was detected in some patients with BPH and malignant prostatic disease, as well as in those with lymph node and bone metastases of prostate cancer. Conclusions: F-18-deoxyglucose PET does not allow for metabolic labeling in the majority of untreated primary prostate cancers. BPH and primary prostate cancer cannot be reliably differentiated on the basis of PET. Increased F-18-deoxyglucose accumulation occurs in some primary prostate tumors and in metastatic deposits of prostate cancer.
引用
收藏
页码:994 / 998
页数:5
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