Synthetic mimetics of the CD4 binding site of HIV-1 gp120 for the design of immunogens

被引：27

作者：

Franke, Raimo ^{[1
]}

Hirsch, Tatjana ^{[1
]}

Overwin, Heike ^{[1
]}

Eichler, Jutta ^{[1
]}

机构：

[1] Helmholtz Ctr Infect Res, D-38124 Braunschweig, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 08期

关键词：

biomimetic synthesis; HIV-1; gp120; peptides; protein design; synthetic vaccines;

D O I：

10.1002/anie.200603274

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Do you copy? The epitope of the broadly neutralizing anti-HIV-1 antibody mAbb12 overlaps the CD4 binding site (CD4bs) of the viral envelope glycoprotein gp120 (see picture). Synthetic mimetics of the CD4bs are therefore promising immunogen candidates to elicit a broadly neutralizing immune response. Polyclonal antisera against such a mimetic molecule specifically recognize gp120 and compete with mAbb12 for binding to gp120. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1253 / 1255

页数：3

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