The adjuvant OM-174 induces both the migration and maturation of murine dendritic cells in vivo

被引：14

作者：

Pajak, B

Garze, V

Davies, G

Bauer, J

Moser, M

Chiavaroli, C ^{[1
]}

机构：

[1] OM PHARMA, CH-1217 Meyrin, Switzerland

[2] Free Univ Brussels, Physiol Anim Lab, B-6041 Gosselies, Belgium

来源：

VACCINE | 2003年 / 21卷 / 9-10期

关键词：

dendritic cells; adjuvant; maturation and migration;

D O I：

10.1016/S0264-410X(02)00529-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aim of this study was to test the capacity of the novel adjuvant OM-174, a lipid A analog, to induce the migration and the maturation of murine dendritic cells (DC) in vivo, a step which is considered as the initiation of the adaptive immune response. BALB/c mice were injected intravenously or subcutaneously with OM-174. The spleen and popliteal lymph nodes were harvested, and analyzed for DC localization and phenotype. The data presented here clearly show that, OM-174 induces the migration of DC from the periphery to the T cell areas of lymphoid organs, and their maturation into cells expressing high levels of MHC class II and co-stimulatory molecules, with a potency close to that of Escherichia coli lipopolysaccharide (LPS). (C) 2002 Elsevier Science Ltd. All rights reserved.

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收藏

页码：836 / 842

页数：7

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