Preparation and Unique pH-Responsive Properties of Novel Biodegradable Nanocapsules Composed of Poly(γ-glutamic acid) and Chitosan as Weak Polyelectrolytes

被引：28

作者：

Imoto, Takayuki ^{[1
]}

Kida, Toshiyuki ^{[1
]}

Matsusaki, Michiya ^{[1
]}

Akashi, Mitsuru ^{[1
,2
]}

机构：

[1] Osaka Univ, Dept Appl Chem, Grad Sch Engn, Suita, Osaka 5650871, Japan

[2] Japan Sci & Technol Agcy, CREST, Tokyo, Japan

来源：

MACROMOLECULAR BIOSCIENCE | 2010年 / 10卷 / 03期

基金：

日本科学技术振兴机构;

关键词：

MULTILAYER FILMS; MICROCAPSULES; RELEASE; PARTICLES; DELIVERY;

D O I：

10.1002/mabi.200900272

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel biodegradable hollow nanocapsules composed of two kinds of weak polyelecrolytes, CT and gamma-PGA, were successfully prepared by the deposition of their LbL-assembled films onto silica particles and the subsequent removal of the silica. These CT-gamma-PGA hollow nanocapsules showed unique size increases at pH = 1.0, due to the swelling of capsule membranes induced by electrostatic repulsions between ammonium groups of CT components. On the other hand, no significant changes in the capsule size were observed at pH = 4.0, 7.0, and 10. By using the CT-gamma-PGA nanocapsules, the release of encapsulated substances in response to acidic pH values was accomplished.

引用

页码：271 / 277

页数：7

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