Class I genes have split from the MHC in the tammar wallaby

被引:31
作者
Deakin, J. E. [1 ]
Siddle, H. V.
Cross, J. G. R.
Belov, K.
Graves, J. A. M.
机构
[1] Australian Natl Univ, Res Sch Biol Sci, ARC Ctr Kangaroo Genom, Canberra, ACT 0200, Australia
[2] Univ Sydney, Fac Vet Sci, Ctr Adv Technol Anim Genet Reprod, Sydney, NSW 2006, Australia
关键词
D O I
10.1159/000098188
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Genes within the Major Histocompatibility Complex (MHC) are critical to the immune response and immunoregulation. Comparative studies have revealed that the MHC has undergone many changes throughout evolution yet in tetrapods the three different classes of MHC genes have maintained linkage, suggesting that there may be some functional advantage obtained by maintaining this clustering of MHC genes. Here we present data showing that class II and III genes, the antigen processing gene TAP2, and MHC framework genes are found together in the tammar wallaby on chromosome 2. Surprisingly class I loci were not found on chromosome 2 but were mapped to ten different locations spread across six chromosomes. This distribution of class I loci in the wallaby on nearly all autosomes is not a characteristic of all marsupials and may be a relatively recent phenomenon. It highlights the need for the inclusion of more than one marsupial species in comparative studies and raises questions regarding the functional significance of the clustering of MHC genes. Copyright (c) 2007 S. Karger AG, Basel
引用
收藏
页码:205 / 211
页数:7
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