Novel aspects of vitamin C:: how important is glypican-1 recycling?

被引：27

作者：

Fransson, Lars-Ake ^{[1
]}

Mani, Katrin ^{[1
]}

机构：

[1] Lund Univ, Biomed Ctr A13, Glycobiol Grp, Div Neurosci,Dept Expt Med Sci, SE-22184 Lund, Sweden

来源：

TRENDS IN MOLECULAR MEDICINE | 2007年 / 13卷 / 04期

关键词：

D O I：

10.1016/j.molmed.2007.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The reduced form of vitamin C, ascorbic acid, is well known for its function as an antioxidant and as a protective agent against scurvy. However, many recent studies indicate other functions for vitamin C in mammalian cells. Novel findings provide possible explanations for observed beneficial effects of a high intake of vitamin C on cell growth, gene transcription, host resistance to infection, uptake of polyamines and clearance of misfolded proteins. Vitamin C exerts its effects indirectly via hypoxia-inducible factor, nitric oxide synthase and the heparan sulfate proteoglycan glypican-1, which is deglycanated in a vitamin C- and copper-dependent reaction.

引用

页码：143 / 149

页数：7

共 59 条

[51] Kinetics and mechanism of the decomposition of S-nitrosoglutathione by L-ascorbic acid and copper ions in aqueous solution to produce nitric oxide [J].