Preparation by coaxial electrospinning and characterization of membranes releasing (-) epicatechin as scaffold for tissue engineering

被引：21

作者：

Castillo-Ortega, M. M. ^{[1
]}

Montano-Figueroa, A. G. ^{[1
]}

Rodriguez-Felix, D. E. ^{[1
]}

Prado-Villegas, G. ^{[2
]}

Pino-Ocano, K. P. ^{[1
]}

Valencia-Cordova, M. J. ^{[1
]}

Quiroz-Castillo, J. M. ^{[1
]}

Herrera-Franco, P. J. ^{[3
]}

机构：

[1] Univ Sonora, Dept Invest Polimeros & Mat, Hermosillo 83000, Sonora, Mexico

[2] Ctr Med Nacl Siglo XXI, Mexico City 06720, DF, Mexico

[3] Ctr Invest Cient Yucatan, Merida, Yucatan, Mexico

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2015年 / 46卷

关键词：

Electrospinning; Epicatechin; Fiber; Drug delivery; Tissue engineering; CELLULOSE-ACETATE; IN-VITRO; BIOCOMPATIBILITY; FIBERS; (-)-EPICATECHIN; NANOFIBERS; COCOA;

D O I：

10.1016/j.msec.2014.10.031

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

Optimal conditions for the preparation of a composite material of fibers of cellulose acetate (CA) and poly(vinyl pyrrolidone) (PVP), containing epicatechin (Epic) within the fiber CA/PVP-Epic/CA, were found. The morphology and physical/chemical properties of the fibrous membranes containing CA, PVP, and epicatechin were characterized using FTIR spectroscopy, thermal analysis, SEM, TEM, and natural weathering. Also, mechanical characterization of the fibers showed that tensile strength of the membrane was not affected by the presence of epicatechin within the fiber as compared with fibers without epicatechin. The effect of the medium on the release rate of epicatechin was also studied. The amount of epicatechin release was higher in water, 79.6%, and 31% in MesenCult medium. These results showed that these composite materials are recommended for cardiac tissue engineering; furthermore, using these materials allows precise release of the epicatechin in the damaged tissue. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：184 / 189

页数：6

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