Applications of genetically manipulated mice in pharmacogenetics and pharmacogenomics

被引：10

作者：

Kimura, S ^{[1
]}

Gonzalez, F ^{[1
]}

机构：

[1] NCI, Lab Metab, NIH, Bethesda, MD 20892 USA

来源：

PHARMACOLOGY | 2000年 / 61卷 / 03期

关键词：

cytochrome P450; xenobiotic-metabolizing enzymes; gene knockout mouse; transgenic mouse; pharmacogenetics; pharmacogenomics;

D O I：

10.1159/000028395

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gene knockout mice have proven to be very useful in understanding the role of xenobiotic-metabolizing enzymes in chemical toxicity and carcinogenesis, The combination of gene knockout technology with transgenic mouse technology should provide more versatile and suitable animal models to study the risks of chemical exposures in humans in terms of toxicity and carcinogenesis, as well as development and design of new therapeutic drugs, Recent studies using genetically manipulated mice are summarized. Copyright (C) 2000 S. Karger AG. Basel.

引用

页码：147 / 153

页数：7

共 36 条

[31] STABILIZATION OF CYTOCHROME-P450J MESSENGER-RIBONUCLEIC-ACID IN THE DIABETIC RAT [J].