Anti-AIDS agents 54.: A potent anti-HIV chalcone and flavonoids from genus Desmos

被引：276

作者：

Wu, JH

Wang, XH

Yi, YH

Lee, KH ^{[1
]}

机构：

[1] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

[2] 306 Hosp PLA, Dept Pharm, Beijing 100101, Peoples R China

[3] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(03)00197-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Sixteen flavonoids and their derivatives isolated from Desmos spp. were evaluated for inhibition of HIV replication in H9 lymphocyte cells. 2-Methoxy-3-methyl-4,6-dihydroxy-5-(3'-hydroxy)cinnamoylbenzaldehyde (12) and lawinal (6) demonstrated potent anti-HIV activity with EC50 values of 0.022 and 2.30 mug/mL and therapeutic indexes of 489 and 45.2, respectively. Compound 12 appears to be an excellent lead for further anti-HIV drug development. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1813 / 1815

页数：3

共 14 条

[1]

*J SU NEW MED COLL, 1977, CHUNG YAO TZU DIEN, V2, P1919

[2] Antimalarial alkoxylated and hydroxylated chalones: Structure-activity relationship analysis [J].

Liu, M ;

Wilairat, P ;

Go, ML .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (25) :4443-4452

[3]

RAGHAVAN K, 1995, BIOCHEM PHARMACOL, V48, P1165

[4]

WANG HK, 1998, ADV EXPT MED BIOL, P438

[5]

WU J, 1994, CHINESE CHEM LETT, V5, P211

[6]

Wu J. H., 1994, Acta Pharmaceutica Sinica, V29, P621

[7]

Wu J.H., 1997, J CHIN PHARM SCI, V6, P119

[8] Desmosdumotin C, a novel cytotoxic principle from Desmos dumosus [J].

Wu, JH ;

McPhail, AT ;

Bastow, KF ;

Shiraki, H ;

Ito, J ;

Lee, KH .

TETRAHEDRON LETTERS, 2002, 43 (08) :1391-1393

[9]

Wu JH, 2001, CHINESE CHEM LETT, V12, P49

[10]

WU JH, 2000, CHIN TRAD HERBAL DRU, V31, P567

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