共 90 条
White matter pathology isolates the hippocampal formation in Alzheimer's disease
被引:218
作者:
Salat, D. H.
[1
,2
]
Tuch, D. S.
[2
]
van der Kouwe, A. J. W.
[2
]
Greve, D. N.
[2
]
Pappu, V.
[3
]
Lee, S. Y.
[3
]
Hevelone, N. D.
[3
]
Zaleta, A. K.
[3
]
Growdon, J. H.
[3
]
Corkin, S.
[4
]
Fischl, B.
[2
]
Rosas, H. D.
[3
]
机构:
[1] MGH MIT HMS Athinoula A Martinos Ctr Biomed Imagi, MGH Dept Radiol, Charlestown, MA 02129 USA
[2] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA
[4] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA
关键词:
Alzheimer;
Aging;
Diffusion tensor imaging;
Fractional anisotropy;
Diffusivity;
MRI;
White matter;
Dementia;
Hippocampus;
Entorhinal;
Memory;
Axial diffusivity;
Radial diffusivity;
Tractography;
Volume;
Hyperintensities;
T2;
Myelin;
Axon;
MILD COGNITIVE IMPAIRMENT;
DIFFUSION-TENSOR;
MEMORY IMPAIRMENT;
IN-VIVO;
DEMENTIA;
MRI;
BRAIN;
AGE;
CORTEX;
DEGENERATION;
D O I:
10.1016/j.neurobiolaging.2008.03.013
中图分类号:
R592 [老年病学];
C [社会科学总论];
学科分类号:
03 ;
0303 ;
100203 ;
摘要:
Prior work has demonstrated that the memory dysfunction of Alzheimer's disease (AD) is accompanied by marked cortical pathology in medial temporal lobe (MTL) gray matter. In contrast, changes in white matter (WM) of pathways associated with the MTL have rarely been studied. We used diffusion tensor imaging (DTI) to examine regional patterns of WM tissue changes in individuals with AD. Alterations of diffusion properties with AD were found in several regions including parahippocampal WM, and in regions with direct and secondary connections to the MTL. A portion of the changes measured, including effects in the parahippocampal WM, were independent of gray matter degeneration as measured by hippocampal volume. Examination of regional changes in unique diffusion parameters including anisotropy and axial and radial diffusivity demonstrated distinct zones of alterations, potentially stemming from differences in underlying pathology, with a potential myelin specific pathology in the parahippocampal WM. These results demonstrate that deterioration of neocortical connections to the hippocampal formation results in part from the degeneration of critical MTL and associated fiber pathways. (C) 2008 Elsevier Inc. All rights reserved.
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页码:244 / 256
页数:13
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