Chiral ferrocenyl amino alcohols as analogues of norephedrine catalysts for enantioselective addition of diethylzinc to benzaldehyde

被引：16

作者：

Bastin, S ^{[1
]}

Brocard, J ^{[1
]}

Pélinski, L ^{[1
]}

机构：

[1] ENSCL, Lab Catalyse Lille, Grp Synth Organomet, UPRESA 8010, F-59652 Villeneuve Dascq, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 38期

关键词：

ferrocenyl amino alcohols; diethylzinc; enantioselective alkylation;

D O I：

10.1016/S0040-4039(00)01209-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optically active ferrocenyl amino alcohols have been prepared from commercially available L-alaninol and L-leucinol. They have been used in catalytic amounts as chiral ligands in the addition of diethylzinc to benzaldehyde. 1-Phenylpropanol has thus been obtained in up to 95% enantiomeric excess. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7303 / 7307

页数：5

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