Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL-4 and STAT6

被引：127

作者：

Chapoval, Svetlana ^{[2
]}

Dasgupta, Preeta ^{[2
]}

Dorsey, Nicolas J. ^{[2
]}

Keegan, Achsah D. ^{[1
,2
]}

机构：

[1] Univ Maryland, Sch Med, CVID, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Program Oncol, Marlene & Stewart Greenebaum Canc Ctr, Baltimore, MD 21201 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2010年 / 87卷 / 06期

基金：

美国国家卫生研究院;

关键词：

allergy; lymphoid cell-mediated immunity; T cell responses; signal transduction; Foxp3; GROWTH-FACTOR-BETA; TGF-BETA; IN-VIVO; AIRWAY HYPERRESPONSIVENESS; IMMUNE-RESPONSES; SUPPRESSOR FUNCTION; DENDRITIC CELLS; CUTTING EDGE; REG CELLS; FOXP3;

D O I：

10.1189/jlb.1209772

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During the development of immune responses to pathogens, self-antigens, or environmental allergens, naive CD4(+) T cells differentiate into subsets of effector cells including Th1, Th2, and Th17 cells. The differentiation into these subsets is controlled by specific transcription factors. The activity of these effector cells is limited by nTregs and iTregs, whose differentiation and maintenance are dependent on the transcription factor Foxp3. The regulation of autoimmune diseases mediated by Th1 and Th17 cells by Tregs has been studied and reviewed extensively. However, much less has been presented about the interplay between Tregs and Th2 cells and their contribution to allergic disease. In this perspective, we discuss the regulation of Th2 cells by Tregs and vice versa, focusing on the interplay between the IL-4-activated STAT6/GATA3 pathway and Foxp3. J. Leukoc. Biol. 87: 1011-1018; 2010.

引用

页码：1011 / 1018

页数：8

共 102 条

[71] Prolonged antigen exposure ameliorates airway inflammation but not remodeling in a mouse model of bronchial asthma
Sakai, K
Yokoyama, A
Kohno, N
Hamada, H
Hiwada, K
[J]. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2001, 126 (02) : 126 - 134
[72] Competition for cytokines:: Treg cells take all
Scheffold, Alexander
Murphy, Kenneth M.
Hoefer, Thomas
[J]. NATURE IMMUNOLOGY, 2007, 8 (12) : 1285 - 1287
[73] Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression
Shevach, Ethan M.
[J]. IMMUNITY, 2009, 30 (05) : 636 - 645
[74] Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
Shimoda, K
vanDeursen, J
Sangster, MY
Sarawar, SR
Carson, RT
Tripp, RA
Chu, C
Quelle, FW
Nosaka, T
Vignali, DAA
Doherty, PC
Grosveld, G
Paul, WE
Ihle, JN
[J]. NATURE, 1996, 380 (6575) : 630 - 633
[75] The IL-4 receptor α-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursors
Skapenko, A
Kalden, JR
Lipsky, PE
Schulze-Koops, H
[J]. JOURNAL OF IMMUNOLOGY, 2005, 175 (09) : 6107 - 6116
[76] Memory T cell proliferation in cow's milk allergy after CD25+ regulatory T cell removal suggests a role for casein-specific cellular immunity in IgE-mediated but not in non-IgE-mediated cow's milk allergy
Sletten, Gaynour B. G.
Halvorsen, Ragnhild
Egaas, Eliann
Halstensen, Trond S.
[J]. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2007, 142 (03) : 190 - 198
[77] Chronic exposure to innocuous leads to suppressed airway antigen in sensitized mice eosinophilia that is reversed by granulocyte macrophage colony-stimulating factor
Swirski, FK
Sajic, D
Robbins, CS
Gajewska, BU
Jordana, M
Stämpfli, MR
[J]. JOURNAL OF IMMUNOLOGY, 2002, 169 (07) : 3499 - 3506
[78] Taams LS, 2002, EUR J IMMUNOL, V32, P1621, DOI 10.1002/1521-4141(200206)32:6<1621::AID-IMMU1621>3.0.CO
[79] 2-Q
[80] Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells:: induction of autoimmune disease by breaking their anergic/suppressive state
Takahashi, T
Kuniyasu, Y
Toda, M
Sakaguchi, N
Itoh, M
Iwata, M
Shimizu, J
Sakaguchi, S
[J]. INTERNATIONAL IMMUNOLOGY, 1998, 10 (12) : 1969 - 1980

← 2 3 4 5 6 7 8 9 10 11 →