Cytotoxic prenylflavanones from Taiwanese propolis

被引：85

作者：

Chen, CN

Wu, CL

Shy, HS

Lin, JK

机构：

[1] Natl Taiwan Univ, Coll Med, Grad Inst Biochem & Mol Biol, Taipei 100, Taiwan

[2] Tamkang Univ, Dept Chem, Tamsui 251, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 04期

关键词：

D O I：

10.1021/np0203180

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new prenylflavanones, propolin A (2) and propolin B (3), were isolated and characterized from Taiwanese propolis. Both compounds were found to have cytotoxic properties against three cancer cell lines. DNA content analyses and DNA fragmentation indicated that propolin A (2) efficiently induced apoptosis in cancer cell lines, but had no effect on the cell cycle program. Furthermore, both propolin A (2) and B (3) are potential antioxidant agents and show strong scavenging effects against most types of free radicals.

引用

页码：503 / 506

页数：4

共 13 条

[1] INVITRO ANTIVIRAL ACTIVITY OF PROPOLIS [J].