Bronsted acid-catalyzed benzylation of 1,3-dicarbonyl derivatives

被引：116

作者：

Sanz, Roberto

Miguel, Delia

Martinez, Alberto

Alvarez-Gutierrez, Julia M.

Rodriguez, Felix

机构：

[1] Univ Burgos, Dept Quim, Area Quim Organ, Fac Ciencias, Burgos 09001, Spain

[2] Univ Oviedo, Inst Univ Quim Organomet Enrique Moles, E-33006 Oviedo, Spain

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 10期

关键词：

D O I：

10.1021/ol070624a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct alkylation of 1,3-dicarbonyl compounds with benzylic alcohols is shown to be efficiently catalyzed by simple Bronsted acids such as triflic acid (TfOH) and p-toluenesulfonic acid (PTS) to give rise to monoalkylated dicarbonyl derivatives in high yields. In the absence of the nucleophile, substituted alkenes, generated through a formal dimerization reaction, are obtained. The reactions are carried out in air using undried solvents, with water being the only side product of the process.

引用

页码：2027 / 2030

页数：4

共 25 条

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