Distribution of body weight, blood insulin and lipid levels in the SMXA recombinant inbred strains and the QTL analysis

被引：39

作者：

Anunciado, RVP

Ohno, T

Mori, M

Ishikawa, A

Tanaka, S

Horio, F

Nishimura, M

Namikawa, T

机构：

[1] Nagoya Univ, Grad Sch Bioagr Sci, Lab Anim Genet, Chikusa Ku, Nagoya, Aichi 4648601, Japan

[2] Nagoya Univ, Sch Med, Inst Lab Anim Res, Showa Ku, Nagoya, Aichi 4668550, Japan

[3] Shinshu Univ, Sch Med, Res Ctr Aging & Adaptat, Dept Aging Angiol, Matsumoto, Nagano 3908621, Japan

[4] Natl Chubu Hosp, Natl Inst Longev Sci, Aichi 4740031, Japan

[5] Nagoya Univ, Grad Sch Bioagr Sci, Div Biomodelling, Chikusa Ku, Nagoya, Aichi 4648601, Japan

[6] Univ Philippines, Coll Vet Med, Laguna 4031, Philippines

来源：

EXPERIMENTAL ANIMALS | 2000年 / 49卷 / 03期

关键词：

blood insulin; blood lipids; body weight; quantitative trait loci (QTL) analysis; SMXA recombinant inbred (RI) strains;

D O I：

10.1538/expanim.49.217

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

In the SMXA recombinant inbred (RI) strains, we measured body weight, blood insulin and lipid (triglyceride, total cholesterol and phospholipid) levels in each strain. In the five traits, mean values of substrains varied remarkably and showed a continuous spectrum of distribution, suggesting control by multiple genes at distinct loci for each trait. We also screened for quantitative trait loci (QTLs) involved in the five traits. Suggestive QTLs for body weight (Chromosomes 1 and 6), insulin (Chromosomes 1, 3, 10 and 17), triglyceride (Chromosomes 4 and 11) and phospholipid (Chromosome 18) levels were detected The SMXA RI strains are unique fools for analyzing genetic factors that influence body weight, blood insulin and lipids levels.

引用

页码：217 / 224

页数：8

共 23 条

[21] GENETIC-FACTORS IN LIPOPROTEIN METABOLISM - ANALYSIS OF A GENETIC CROSS BETWEEN INBRED MOUSE STRAINS NZB/BINJ AND SM/J USING A COMPLETE LINKAGE MAP APPROACH [J].