Passerini Three-Component Reaction of Alcohols under Catalytic Aerobic Oxidative Conditions

被引：79

作者：

Brioche, Julien ^{[1
]}

Masson, Geraldine ^{[1
]}

Zhu, Jieping ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, Ctr Rech Gif, F-91198 Gif Sur Yvette, France

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 07期

关键词：

TRANSITION-METAL-FREE; MULTICOMPONENT REACTIONS; ASYMMETRIC-SYNTHESIS; ORGANIC-COMPOUNDS; EFFICIENT; ALDEHYDES; KETONES; TEMPO; COMPLEX; SYSTEM;

D O I：

10.1021/ol100012y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alcohols instead of aldehydes were used in the Passerini three-component reaction under catalytic aerobic conditions. Mixing alcohols, Isocyanides, and carboxylic acids in toluene In the presence of a catalytic amount of cupric chloride, NaNO2, and TEMPO afforded, under an oxygen atmosphere, the P-3CR adducts in good yields.

引用

页码：1432 / 1435

页数：4

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