Glycoprotein degradation: Do sugars hold the key?

被引：26

作者：

Frigerio, L ^{[1
]}

Lord, JM ^{[1
]}

机构：

[1] Univ Warwick, Dept Biol Sci, Coventry CV4 7AL, W Midlands, England

来源：

CURRENT BIOLOGY | 2000年 / 10卷 / 18期

关键词：

D O I：

10.1016/S0960-9822(00)00680-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Secretory glycoproteins that fail to fold or assemble correctly are retained in the endoplasmic reticulum and eventually degraded. Recent evidence shows that trimming of their N-linked oligosaccharide chains plays a key role in targeting glycoproteins for destruction.

引用

页码：R674 / R677

页数：4

共 17 条

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