Cecropin A melittin hybrid peptide exerts its antifungal effects by damaging on the plasma membranes of Trichosporon beigelii

被引：16

作者：

Lee, DG ^{[1
]}

Shin, SY ^{[1
]}

Maeng, CY ^{[1
]}

Hahm, KS ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Peptide Engn Res Unit, Taejon 305600, South Korea

来源：

BIOTECHNOLOGY LETTERS | 1998年 / 20卷 / 03期

关键词：

D O I：

10.1023/A:1005357314588

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

To elucidate the effect of the peptide derived from cecropin A(1-8)-melittin(1-12) having potent antifungal activity without cytotoxicity against eukaryotic cell on the fungal cell membranes, Trichosporon beigelii protoplasts were prepared. The protoplasts treated with the peptide not only failed to regenerate the fungal cell walls but also disrupted the membrane, indicating that the peptide exerts its antifungal activity by acting on the plasma membranes.

引用

页码：211 / 214

页数：4

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