Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain

被引：67

作者：

Dicou, E

Rangon, CM

Guimiot, F

Spedding, M

Gressens, P

机构：

[1] Inst Rech Int Servier, F-92200 Paris, France

[2] Hop Robert Debre, INSERM, E9935, F-75019 Paris, France

来源：

BRAIN RESEARCH | 2003年 / 970卷 / 1-2期

关键词：

positive allosteric modulators of AMPA receptors; neuroprotection; ibotenate; BDNF; newborn mouse;

D O I：

10.1016/S0006-8993(03)02357-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Four positive modulators of AMPA-type glutamate receptors (cyclothiazide, CX614, LY404187 and S18986-1) given in acute or chronic manner exerted a neuroprotective effect in lesions induced in postnatal day 5 (P5) mice by intracerebral injection of ibotenate, an NMDA agonist. The neuroprotective effects were mediated via the MAPK pathway since coinjection of the MEK inhibitor, PD98059, blocked the neuroprotective effects. Administration of CX614 to neonatal mice was followed by upregulation of hippocampal and cortical BDNF expression. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：221 / 225

页数：5

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