Isolation of ginkgolides A, B, C, J and bilobalide from G-biloba extracts

被引：52

作者：

Jaracz, S ^{[1
]}

Malik, S ^{[1
]}

Nakanishi, K ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

PHYTOCHEMISTRY | 2004年 / 65卷 / 21期

关键词：

Ginkgo biloba; Ginkgoaceae; isolation; terpenes; ginkgolides; bilobalide;

D O I：

10.1016/j.phytochem.2004.08.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ginkgolides A, B, C and J, together with bilobalide, are unique terpenoid components of the Ginkgo biloba tree. Due to similar chemical properties, their separation is quite tedious. We have developed an efficient and rapid protocol for separation of individual ginkgolides and bilobalide from G. biloba extracts. The procedure takes advantage of enhanced susceptibility of ginkgolides B and C to benzylation and the ease of separation of these products from ginkgolides A and J which do not react. The protocol is applicable to the previously reported enriched extracts prepared from G. biloba leaves. A single chromatographic step prior to benzylation provides bilobalide and mixture of ginkgolides A, B, C, and J. After benzylation, the individual ginkgolides are separated by chromatography. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2897 / 2902

页数：6

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