Structures of staurosporine bound to CDK2 and cAPK - new tools for structure-based design of protein kinase inhibitors

被引：66

作者：

Toledo, LM ^{[1
]}

Lydon, NB ^{[1
]}

机构：

[1] Kinetix Pharmaceut Inc, Medford, MA 02155 USA

来源：

STRUCTURE | 1997年 / 5卷 / 12期

关键词：

D O I：

10.1016/S0969-2126(97)00304-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein kinases are involved in a wide variety of signal transduction processes; their deregulation has been implicated in a number of human diseases, including cancer and disorders of the immune system. The recently determined structures of two protein kinases, cAPK and CDK2, in complex with an inhibitor, staurosporine, provide a detailed account of inhibitor-kinase interactions and inhibitor selectivity.

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页码：1551 / 1556

页数：6

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