Dialogue between skin microbiota and immunity

被引：498

作者：

Belkaid, Yasmine ^{[1
,2
]}

Segre, Julia A. ^{[3
]}

机构：

[1] NIAID, Program Barrier Immun & Repair, NIH, Bethesda, MD 20892 USA

[2] NIAID, Mucosal Immunol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

[3] NHGRI, Microbial Genom Sect, Translat & Funct Genom Branch, NIH, Bethesda, MD 20892 USA

来源：

SCIENCE | 2014年 / 346卷 / 6212期

基金：

美国国家卫生研究院;

关键词：

STAPHYLOCOCCUS-EPIDERMIDIS; ANTIMICROBIAL PEPTIDES; DENDRITIC CELLS; COLONIZATION RESISTANCE; PROPIONIBACTERIUM-ACNES; GENOME SEQUENCE; GUT MICROBIOTA; DIVERSITY; DISEASE; INFLAMMATION;

D O I：

10.1126/science.1260144

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human skin, the body's largest organ, functions as a physical barrier to bar the entry of foreign pathogens, while concomitantly providing a home to myriad commensals. Over a human's life span, keratinized skin cells, immune cells, and microbes all interact to integrate the processes of maintaining skin's physical and immune barrier under homeostatic healthy conditions and also under multiple stresses, such as wounding or infection. In this Review, we explore the intricate interactions of microbes and immune cells on the skin surface and within associated appendages to regulate this orchestrated maturation in the context of both host physiological changes and environmental challenges.

引用

页码：954 / 959

页数：6

共 67 条

[1] Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood:: ISAAC Phases One and Three repeat multicountry cross-sectional surveys [J].

Asher, M. Innes ;

Montefort, Stephen ;

Bjorksten, Bengt ;

Lai, Christopher K. W. ;

Strachan, David P. ;

Weiland, Stephan K. ;

Williams, Hywel .

LANCET, 2006, 368 (9537) :733-743

[2] Acne is not associated with yet-uncultured bacteria [J].

Bek-Thomsen, M. ;

Lomholt, H. B. ;

Kilian, M. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 46 (10) :3355-3360

[3] Role of the Microbiota in Immunity and Inflammation [J].

Belkaid, Yasmine ;

Hand, Timothy W. .

CELL, 2014, 157 (01) :121-141

[4] The burden of skin diseases: 2004 - A joint project of the American Academy of Dermatology Association and the Society for Investigative Dermatology [J].

Bickers, David R. ;

Lim, Henry W. ;

Margolis, David ;

Weinstock, Martin A. ;

Goodman, Clifford ;

Faulkner, Eric ;

Gould, Ciara ;

Gemmen, Eric ;

Dall, Tim .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2006, 55 (03) :490-500

[5] STEM CELL PLASTICITY Plasticity of epithelial stem cells in tissue regeneration [J].

Blanpain, Cedric ;

Fuchs, Elaine .

SCIENCE, 2014, 344 (6189) :1243-+

[6] Microbiota-mediated colonization resistance against intestinal pathogens [J].

Buffie, Charlie G. ;

Pamer, Eric G. .

NATURE REVIEWS IMMUNOLOGY, 2013, 13 (11) :790-801

[7] A systematic review of treatments for guttate psoriasis [J].

Chalmers, RJG ;

O'Sullivan, T ;

Owen, CM ;

Griffiths, CEM .

BRITISH JOURNAL OF DERMATOLOGY, 2001, 145 (06) :891-894

[8] Complement modulates the cutaneous microbiome and inflammatory milieu [J].

Chehoud, Christel ;

Rafail, Stavros ;

Tyldsley, Amanda S. ;

Seykora, John T. ;

Lambris, John D. ;

Grice, Elizabeth A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (37) :15061-15066

[9] The vast majority of CLA+ T cells are resident in normal skin [J].

Clark, Rachael A. ;

Chong, Benjamin ;

Mirchandani, Nina ;

Brinster, Nooshin K. ;

Yamanaka, Kei-ichi ;

Dowgiert, Rebecca K. ;

Kupper, Thomas S. .

JOURNAL OF IMMUNOLOGY, 2006, 176 (07) :4431-4439

[10] Staphylococcus epidermidis pan-genome sequence analysis reveals diversity of skin commensal and hospital infection-associated isolates [J].

Conlan, Sean ;

Mijares, Lilia A. ;

Becker, Jesse ;

Blakesley, Robert W. ;

Bouffard, Gerard G. ;

Brooks, Shelise ;

Coleman, Holly ;

Gupta, Jyoti ;

Gurson, Natalie ;

Park, Morgan ;

Schmidt, Brian ;

Thomas, Pamela J. ;

Otto, Michael ;

Kong, Heidi H. ;

Murray, Patrick R. ;

Segre, Julia A. .

GENOME BIOLOGY, 2012, 13 (07)

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