Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid β-protein

被引：427

作者：

Selkoe, Dennis J. ^{[1
,2
,3
]}

机构：

[1] Harvard Med Sch, Dept Neurol, Boston, MA 02115 USA

[2] Harvard Med Sch, Program Neurosci, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2001年 / 3卷 / 01期

关键词：

D O I：

10.3233/JAD-2001-3111

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

引用

页码：75 / 81

页数：7

共 21 条

[1] A SEQUENCE OF CYTOSKELETON CHANGES RELATED TO THE FORMATION OF NEUROFIBRILLARY TANGLES AND NEUROPIL THREADS
BRAAK, E
BRAAK, H
MANDELKOW, EM
[J]. ACTA NEUROPATHOLOGICA, 1994, 87 (06) : 554 - 567
[2] Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation
Chui, DH
Tanahashi, H
Ozawa, K
Ikeda, S
Checler, F
Ueda, O
Suzuki, H
Araki, W
Inoue, H
Shirotani, K
Takahashi, K
Gallyas, F
Tabira, T
[J]. NATURE MEDICINE, 1999, 5 (05) : 560 - 564
[3] beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease
Cummings, BJ
Pike, CJ
Shankle, R
Cotman, CW
[J]. NEUROBIOLOGY OF AGING, 1996, 17 (06) : 921 - 933
[4] IMAGE-ANALYSIS OF BETA-AMYLOID LOAD IN ALZHEIMERS-DISEASE AND RELATION TO DEMENTIA SEVERITY
CUMMINGS, BJ
COTMAN, CW
[J]. LANCET, 1995, 346 (8989): : 1524 - 1528
[5] Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1
Esler, WP
Kimberly, WT
Ostaszewski, BL
Diehl, TS
Moore, CL
Tsai, JY
Rahmati, T
Xia, WM
Selkoe, DJ
Wolfe, MS
[J]. NATURE CELL BIOLOGY, 2000, 2 (07) : 428 - 434
[6] Aging renders the brain vulnerable to amyloid β-protein neurotoxicity
Geula, C
Wu, CK
Saroff, D
Lorenzo, A
Yuan, ML
Yankner, BA
[J]. NATURE MEDICINE, 1998, 4 (07) : 827 - 831
[7] Intraneuronal Aβ42 accumulation in human brain
Gouras, GK
Tsai, J
Naslund, J
Vincent, B
Edgar, M
Checler, F
Greenfield, JP
Haroutunian, V
Buxbaum, JD
Xu, HX
Greengard, P
Relkin, NR
[J]. AMERICAN JOURNAL OF PATHOLOGY, 2000, 156 (01) : 15 - 20
[8] The Alzheimer family of diseases: Many etiologies, one pathogenesis?
Hardy, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) : 2095 - 2097
[9] Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
Hutton, M
Lendon, CL
Rizzu, P
Baker, M
Froelich, S
Houlden, H
Pickering-Brown, S
Chakraverty, S
Isaacs, A
Grover, A
Hackett, J
Adamson, J
Lincoln, S
Dickson, D
Davies, P
Petersen, RC
Stevens, M
de Graaff, E
Wauters, E
van Baren, J
Hillebrand, M
Joosse, M
Kwon, JM
Nowotny, P
Che, LK
Norton, J
Morris, JC
Reed, LA
Trojanowski, J
Basun, H
Lannfelt, L
Neystat, M
Fahn, S
Dark, F
Tannenberg, T
Dodd, PR
Hayward, N
Kwok, JBJ
Schofield, PR
Andreadis, A
Snowden, J
Craufurd, D
Neary, D
Owen, F
Oostra, BA
Hardy, J
Goate, A
van Swieten, J
Mann, D
Lynch, T
[J]. NATURE, 1998, 393 (6686) : 702 - 705
[10] Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
Li, YM
Xu, M
Lai, MT
Huang, Q
Castro, JL
DiMuzio-Mower, J
Harrison, T
Lellis, C
Nadin, JL
Neduvelil, JG
Register, RB
Sardana, MK
Shearman, MS
Smith, AL
Shi, XP
Yin, KC
Shafer, JA
Gardell, SJ
[J]. NATURE, 2000, 405 (6787) : 689 - 694

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