Interactions of apolipoprotein E genotype and dietary fat intake of healthy older persons during mid-adult life

被引:40
作者
Petot, GJ
Traore, F
Debanne, SM
Lerner, AJ
Smyth, KA
Friedland, RP
机构
[1] Cleveland State Univ, Memory & Aging Ctr, Dept Nutr, Cleveland, OH 44120 USA
[2] Case Western Reserve Univ, Sch Med, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Sch Med, Dept Biostat, Cleveland, OH 44106 USA
[4] Univ Hosp Cleveland, Cleveland, OH USA
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 2003年 / 52卷 / 03期
关键词
D O I
10.1053/meta.2003.50066
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In a case control study of genetic and lifestyle risk factors for Alzheimer's disease (AD), we obtained recalled food consumption frequencies translated to nutrients and averaged over 2 age periods of adult life, 20 to 39 and 40 to 59 years. The proportion of controls with the apolipoprotein E epsilon4 (APOE epsilon4) genotype was significantly higher in the lowest tertile of fat consumption (36.3% of energy) compared with controls with epsilon4 in the highest tertile of fat intake (44.6% of energy). Healthy older persons with the epsilon4 allele who survived to be included in this study may be protected with lower dietary fat intake and other healthy behaviors. Diet-genotype interactions may have important influences on disorders of later life. Copyright 2003, Elsevier Science (USA). All rights reserved.
引用
收藏
页码:279 / 281
页数:3
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