Acortatarins A and B, Two Novel Antioxidative Spiroalkaloids with a Naturally Unusual Morpholine Motif from Acorus tatarinowii

被引：80

作者：

Tong, Xiao-Gang ^{[2
,3
]}

Zhou, Li-Li ^{[1
]}

Wang, Yue-Hu ^{[2
]}

Xia, Chengfeng ^{[2
]}

Wang, Ye ^{[4
,5
]}

Liang, Min

Hou, Fan-Fan ^{[1
]}

Cheng, Yong-Xian ^{[2
]}

机构：

[1] So Med Univ, Div Nephrol, Nanfang Hosp, Key Lab Organ Failure Res,Educ Minist, Guangzhou 510515, Guangdong, Peoples R China

[2] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

[4] Chinese Acad Sci, Guiyang 550002, Guizhou, Peoples R China

[5] Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Guizhou, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 08期

关键词：

HIGH-GLUCOSE; ACTIVATION; EXPRESSION; INHIBITORS; PRODUCTS;

D O I：

10.1021/ol100451p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Acortatarins A (1) and B (2), two novel spiroalkaloids with a naturally unusual morpholine motif, were isolated from the rhizome of Acorus tatarinowii. Their structures with absolute configuration were determined by spectroscopic methods, X-ray diffraction analysis, and Masher's method. Importantly, compound 1 could significantly inhibit reactive oxygen species production in high-glucose-stimulated mesangial cells in a dose- and time-dependent manner.

引用

页码：1844 / 1847

页数：4

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