Hepatoprotective pyrrole derivatives of Lycium chinense fruits

被引：108

作者：

Chin, YW

Lim, SW

Kim, SH

Shin, DY

Suh, YG

Kim, YB

Kim, YC

Kim, J ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 151742, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(02)00846-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As a part of our search for hepatoprotective compounds from Lycium chinense fruits, three new pyrrole derivatives (1-3) were isolated. These compounds and a related synthetic methylated compound (4) were evaluated for their biological activity and structure-activity relationship, and compounds 1 and 2 showed hepatoprotective effects comparable to silybin at the concentration of 0.1 muM (64.4 and 65.8%, respectively). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：79 / 81

页数：3

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