Two new biologically active triterpene saponins from Acanthophyllum squarrosum

被引：28

作者：

Gaidi, G

Miyamoto, T

Rustaiyan, A

Laurens, V

Lacaille-Dubois, MA

机构：

[1] Univ Bourgogne, Fac Pharm, Lab Pharmacognosie, Unite MIB, F-21079 Dijon, France

[2] Kyushu Univ, Grad Sch Pharmaceut Sci, Fukuoka, Japan

[3] Shahid Beheshti Univ, Dept Chem, Tehran, Iran

[4] Univ Bourgogne, Fac Sci, Grp Immunol Comparee, CNRS,UMR 5548, F-21079 Dijon, France

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 11期

关键词：

D O I：

10.1021/np000212+

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two novel triterpenoid saponins (1 and 2) have been isolated from the roots of Acanthophyllum squarrosum. The structures were established mainly by a combination of 1D NMR techniques as 3-O-beta -D-galactopyranosyl-(1 -->2)-[beta -D-xylopyranosyl-(1 -->3)]-beta -D-glucuronopyranosylgypsogenin-28-O-beta- lopyranosyl-(1 -->3)-beta -D-xylopyranosyl-(1 -->4)-alpha -L-rhamnopyranosylsyl-(1 -->4)-[alpha -L-rhamnopyranosyl-(1 -->3)]-beta -D-fucopyranoside (1) and 3-O-beta -D-glucopyranosylgypsogenin-28-O-alpha -L-rhamnopyranosyl-(1 -->2)-alpha -L-arabinopyranosyl-(1 -->2)-[beta -D-glucopyranosyl-(1 -->6)]-beta -D-glucopyranoside (2). Compound 1 showed a moderate concentration-dependent immunomodulatory effect in an in vitro lymphocyte proliferation assay.

引用

页码：1497 / 1502

页数：6

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