The biological role of strontium

被引：602

作者：

Nielsen, SP ^{[1
]}

机构：

[1] Cent Hosp Hillerod, Dept Clin Physiol, DK-3400 Hillerod, Denmark

来源：

BONE | 2004年 / 35卷 / 03期

关键词：

strontium; physiology; bone; medicine;

D O I：

10.1016/j.bone.2004.04.026

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review summarises old and more recent literature on the biological role of the bone-seeking trace metal strontium (Sr). It covers areas of chemistry, nutrition, toxicity, transport across biological membranes, homeostasis, general physiology, calcium-strontium interactions, and particularly the role of strontium in bone. The promoting action of strontium on calcium uptake into bone at moderate strontium supplementation, and the rachitogenic action of strontium at higher dietary strontium levels are emphasised. The literature is surnmarised of the novel antiosteoporotic drug strontium ranelate, which appears to act by a combination of reduced bone resorption and increased uptake of calcium into bone. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：583 / 588

页数：6

共 66 条

[51]

REGINSTER JY, 2002, OSTEOPOROS INT S3, V13

[52] Strontium causes osteomalacia in chronic renal failure rats [J].

Schrooten, I ;

Cabrera, W ;

Goodman, WG ;

Dauwe, S ;

Lamberts, LV ;

Marynissen, R ;

Dorriné, W ;

De Broe, ME ;

D'Haese, PC .

KIDNEY INTERNATIONAL, 1998, 54 (02) :448-456

[53]

SHORR E, 1952, Bull Hosp Joint Dis, V13, P59

[54]

SKORYNA SC, 1985, HDB STABLE STRONTIUM, P593

[55]

Snyder W.S., 1974, Report of the Task Group on Reference Man

[56] Spectrum of renal bone disease in end-stage renal failure patients not yet on dialysis [J].

Spasovski, GB ;

Bervoets, ARJ ;

Behets, GJS ;

Ivanovski, N ;

Sikole, A ;

Dams, G ;

Couttenye, MM ;

De Broe, ME ;

D'Haese, PC .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2003, 18 (06) :1159-1166

[57] Calcium-induced release of strontium ions from the sarcoplasmic reticulum of rat cardiac ventricular myocytes [J].

Spencer, CI ;

Berlin, JR .

JOURNAL OF PHYSIOLOGY-LONDON, 1997, 504 (03) :565-578

[58]

STAUB JF, 2002, AM J PHYSIOL-REG I, V284, pE835

[59]

*US DEP HHS, 2001, TOX PROF STRONT

[60]

*US NAT AC SCI NAT, 1980, MIN TOL DOM AN, P459

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