Room Temperature C-H Activation and Cross-Coupling of Aryl Ureas in Water

被引：168

作者：

Nishikata, Takashi ^{[1
]}

Abela, Alexander R. ^{[1
]}

Lipshutz, Bruce H. ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 04期

关键词：

anilines; aryl urea; C-H activation; palladium; water; CATALYZED INTRAMOLECULAR ARYLATION; PROTON-ABSTRACTION MECHANISM; ANILIDE ORTHO-ARYLATION; DIRECT C-2 ARYLATION; PALLADIUM ACETATE; BOND ACTIVATION; INDOLES; FUNCTIONALIZATION; HETEROARENES; BORYLATION;

D O I：

10.1002/anie.200905967

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Present) Just mix in water'n stir: Pd-catalyzed C-H activation/cross-couplings can be carried out at room temperature in water/surfactant mixtures. The combination of Pd-(OAc)2 and HBF 4 allowed for reactions of aryl ureas with aryl iodides under very mild conditions, using micellar catalysis (see scheme). This reaction is made possible by use of an in situ generated cationic palladium catalyst. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：781 / 784

页数：4

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