Synthesis of α-substituted allylic amines via a modified bruylants reaction

被引：29

作者：

Agami, C ^{[1
]}

Couty, F ^{[1
]}

Evano, G ^{[1
]}

机构：

[1] Univ Paris 06, CNRS, Lab Synthese Asymetr, F-75005 Paris, France

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 14期

关键词：

D O I：

10.1021/ol0059908

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

GRAPHICS Silver tetrafluoroborate, used as an iminium ion promoter from a amino nitriles, is an efficient additive in the Bruylants reaction involving vinylic Grignards. Improved yields of allylic amines were obtained when the starting a-amino nitrile was treated with this silver salt prior to its reaction with the vinylic Grignard. This improvement was not observed in the case of acetylenic Grignards, The reactivity of other vinyl organometallics (M = Zn, Li, Al, Cu, Si) was briefly examined.

引用

页码：2085 / 2088

页数：4

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