Dietary Intervention by Phytochemicals and Their Role in Modulating Coding and Non-Coding Genes in Cancer

被引：75

作者：

Budisan, Liviuta ^{[1
]}

Gulei, Diana ^{[2
]}

Zanoaga, Oana Mihaela ^{[1
]}

Irimie, Alexandra Iulia ^{[3
]}

Chira, Sergiu ^{[1
]}

Braicu, Cornelia ^{[1
]}

Gherman, Claudia Diana ^{[4
,5
]}

Berindan-Neagoe, Ioana ^{[1
,2
,6
]}

机构：

[1] Univ Med & Pharm Iuliu Hatieganu, Res Ctr Funct Genom Biomed & Translat Med, Cluj Napoca 400012, Romania

[2] Univ Med & Pharm Iuliu Hatieganu, MEDFUTURE Res Ctr Adv Med, Cluj Napoca 400012, Romania

[3] Univ Med & Pharm Iuliu Hatieganu, Fac Dent Med, Dept Prosthodont & Dent Mat, 23 Marinescu St, Cluj Napoca 400012, Romania

[4] Surg Clin II, 4-6 Clin St, Cluj Napoca 400006, Romania

[5] Univ Med & Pharm Iuliu Hatieganu, Dept Surg, 8 Victor Babes St, Cluj Napoca 400012, Romania

[6] Oncol Inst Prof Dr Ion Chiricuta, Dept Funct Genom & Expt Pathol, Cluj Napoca 400015, Romania

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 06期

关键词：

phytochemicals; cancer; apoptosis; coding and non-coding RNA; miRNAs; ACID PHENETHYL ESTER; CELL-CYCLE ARREST; DOWN-REGULATES ONCO-MIR-1260B; EPIGALLOCATECHIN GALLATE EGCG; KAEMPFEROL-INDUCED APOPTOSIS; GENISTEIN INDUCES APOPTOSIS; LEUKEMIA HL-60 CELLS; P-GLYCOPROTEIN ABCB1; NF-KAPPA-B; BREAST-CANCER;

D O I：

10.3390/ijms18061178

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Phytochemicals are natural compounds synthesized as secondary metabolites in plants, representing an important source of molecules with a wide range of therapeutic applications. These natural agents are important regulators of key pathological processes/conditions, including cancer, as they are able to modulate the expression of coding and non-coding transcripts with an oncogenic or tumour suppressor role. These natural agents are currently exploited for the development of therapeutic strategies alone or in tandem with conventional treatments for cancer. The aim of this paper is to review the recent studies regarding the role of these natural phytochemicals in different processes related to cancer inhibition, including apoptosis activation, angiogenesis and metastasis suppression. From the large palette of phytochemicals we selected epigallocatechin gallate (EGCG), caffeic acid phenethyl ester (CAPE), genistein, morin and kaempferol, due to their increased activity in modulating multiple coding and non-coding genes, targeting the main hallmarks of cancer.

引用

页数：25

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