Matrilin-3 from chicken cartilage

被引：27

作者：

Belluoccio, D ^{[1
]}

Trueb, B ^{[1
]}

机构：

[1] UNIV BERN, DIV BIOL, MEM INST, CH-3010 BERN, SWITZERLAND

来源：

FEBS LETTERS | 1997年 / 415卷 / 02期

关键词：

cartilage; epidermal growth factor; extracellular matrix; matrilin; subtractive cDNA cloning; von Willebrand factor;

D O I：

10.1016/S0014-5793(97)01126-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By subtractive cDNA cloning we have identified a novel constituent of chicken cartilage termed matrilin-3. This constituent is encoded by a mRNA of 2.2 kbp whose expression is restricted to cartilaginous tissues. The predicted protein is composed of 452 amino acids with a molecular mass of 49 kDa. It contains a single von Willebrand factor A-like domain, four epidermal growth factor-like repeats and an alpha-helical region which may induce the formation of oligomers via a coiled-coil. The primary structure is similar to that of matrilin-1 which is also expressed in a cartilage-specific manner. This similarity suggests that the genes for the two proteins may have evolved from a common ancestor by gene duplication. (C) 1997 Federation of European Biochemical Societies.

引用

页码：212 / 216

页数：5

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