Effects of physicochemical properties and other factors on systemic nasal drug delivery

被引：224

作者：

Behl, CR ^{[1
]}

Pimplaskar, HK ^{[1
]}

Sileno, AP ^{[1
]}

deMeireles, J ^{[1
]}

Romeo, VD ^{[1
]}

机构：

[1] Nastech Pharmaceut Co Inc, Hauppauge, NY 11788 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1998年 / 29卷 / 1-2期

关键词：

nasal delivery; physical chemical properties; absorption factors; intranasal drug delivery; nasal solutions; nasal gels; nasal powders;

D O I：

10.1016/S0169-409X(97)00063-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Focus has been on the nasal mucosa as an alternative route to achieve faster and higher drug absorption. The whole process of determining the feasibility of a drug candidate for nasal delivery begins with appropriate and adequate preformulation studies leading to the development of potential nasal products which are stable, safe and effective. The effects of physicochemical properties, biological factors, and other factors on systemic nasal drug delivery are discussed.

引用

页码：89 / 116

页数：28

共 186 条

[121]

MAYER K, 1944, SCIENCE, V99, P391

[122]

MCCRUMB FR, 1961, AM J DIS CHILD, V101, P689

[123] EFFECTS OF TOPICAL SALINE AND ISOPROTERENOL ON NASAL AIRWAY-RESISTANCE [J].