Transglutaminase antibodies in children with a genetic risk for celiac disease

被引:61
作者
Hoffenberg, EJ
Bao, F
Eisenbarth, GS
Uhlhorn, C
Haas, JE
Sokol, RJ
Rewers, M
机构
[1] Univ Colorado, Sch Med, Barbara Davis Ctr Childhood Diabet,Dept Pediat, Ctr Pediat Inflammatory Bowel Dis,Sect Pediat Gas, Denver, CO USA
[2] Univ Colorado, Sch Med, Dept Prevent Med & Biometr, Denver, CO USA
[3] Univ Colorado, Sch Med, Dept Pathol, Denver, CO 80262 USA
[4] Univ Colorado, Sch Med, Pediat Gen Clin Res Ctr, Denver, CO USA
关键词
D O I
10.1067/mpd.2000.107582
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objectives: The transglutaminase (TG) antibody test is accurate in identifying celiac disease in symptomatic children. We sought to determine the positive predictive value of this test in asymptomatic children at genetic risk for celiac disease. Study design: Asymptomatic children with a genetic risk for celiac disease were studied to investigate the relationships between TC antibody titer, small bowel histology, growth, and clinical features. Small bowel biopsy histology was graded by using the system of Marsh. Results: Of 30 children with a positive TG antibody test result, 21 (70%) had definite (Marsh score 2 or 3) and 4 (13%) had possible (Marsh score 1) biopsy evidence of celiac disease. TG antibody titer correlated with Marsh score (r = 0.569, P < .01). There was an inverse correlation between Marsh score and height z score (r = -0.361, P = .05). Conclusions: In this group of asymptomatic children screened because of a genetic risk, TG antibodies have a positive predictive value of 70% to 83% for biopsy evidence of celiac disease and may identify children before clinical features of celiac disease develop.
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收藏
页码:356 / 360
页数:5
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