Long-term administration of Polygonum multiflorum Thunb. reduces cerebral ischemia-induced infarct volume in gerbils

被引：32

作者：

Chan, YC

Wang, MF

Chen, YC

Yang, DY

Lee, MS

Cheng, FC ^{[1
]}

机构：

[1] Taichung Vet Gen Hosp, Dept Med Res, Taichung 407, Taiwan

[2] Taichung Vet Gen Hosp, Dept Emergency, Taichung 407, Taiwan

[3] Taichung Vet Gen Hosp, Dept Lab Med, Taichung 407, Taiwan

[4] Providence Univ, Dept Nutr, Taichung 433, Taiwan

[5] Chung Shan Med & Dent Coll, Taichung 402, Taiwan

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2003年 / 31卷 / 01期

关键词：

cerebral ischemia; gerbil; Polygonum multiflorum Thunb; 2,3,5-triphenyltetrazolium chloride;

D O I：

10.1142/S0192415X03000734

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Focal cerebral ischemia was produced by an occlusion of the middle cerebral artery for 1, 3 and 24 hours in gerbils. Infarct volumes were determined by 2,3,5-triphenyltetrezolium chloride (TTC) transcardiac perfusion 24 hours after cerebral ischemia. Significant and consistent infarct sizes were produced in gerbils subjected to 24-hour occlusion of the middle cerebral arterey when compared to the 1 and 3-hour occlusion groups. Long term pretreatment of the 50% ethanol extract of Polygonum multiflorum Thunb. for 2 weeks significantly reduced the infarct volume by 50% as compared to that of the 24-hour occlusion group. The results revealed that long term pretreatment of Polygonum multiflorum Thunb. may protect the brain against focal cerebral ischemia.

引用

页码：71 / 77

页数：7

共 15 条

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