Fibroblast-matrix interactions in wound healing and fibrosis

被引：199

作者：

Eckes, B ^{[1
]}

Zigrino, P ^{[1
]}

Kessler, D ^{[1
]}

Holtkötter, O ^{[1
]}

Shephard, P ^{[1
]}

Mauch, C ^{[1
]}

Krieg, T ^{[1
]}

机构：

[1] Univ Cologne, Dept Dermatol, D-50931 Cologne, Germany

来源：

MATRIX BIOLOGY | 2000年 / 19卷 / 04期

关键词：

extracellular matrix deposition; mediators; fibrosis;

D O I：

10.1016/S0945-053X(00)00077-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulation of matrix deposition is a key event in many physiological and pathological situations. It involves the activity of mediators in autocrine and paracrine fashions and the contact of cells with the surrounding extracellular matrix as well. The tightly regulated balance of both mechanisms guarantees rapid and adaptive cellular responses to meet changes in the biological requirements of the environment. Disturbances lead to wound healing defects or the development of fibrosis. The molecular mechanisms for these regulatory events are only partially understood, but involve the activity of integrins and a structural continuum of extracellular matrix-receptor-cytoskeleton-nucleus for transfer of information and the regulation of activated genes. (C) 2000 Elsevier Science B.V./International Society of Matrix Biology. All rights reserved.

引用

页码：325 / 332

页数：8

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