Scaffold targeting drug-resistant colon cancers

被引：25

作者：

Otrubova, Katerina ^{[1
]}

McGuire, Kathleen L. ^{[1
]}

McAlpine, Shelli R. ^{[1
]}

机构：

[1] San Diego State Univ, Dept Chem & Biochem, San Diego, CA 92182 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 50卷 / 09期

关键词：

D O I：

10.1021/jm070088s

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have identified five derivatives of the natural product sansalvamide A that are potent against multiple drug-resistant colon cancer cell lines. These analogs share no structural homology to current colon cancer drugs, are cytotoxic at levels on par with existing drugs treating other cancers, and demonstrate selectivity for drug-resistant colon cancer cell lines over noncancerous cell lines. Thus, we have established sansalvamide A as a privileged structure for treating multiple drug-resistant colon cancers.

引用

页码：1999 / 2002

页数：4

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