Decarboxylation in the synthesis of 4-alkyl-, 4-alkenyl- and 4-acylpyrimidines

被引:2
作者
Herstad, G [1 ]
Benneche, T [1 ]
机构
[1] Univ Oslo, Dept Chem, N-0315 Oslo, Norway
关键词
D O I
10.1002/jhet.5570400204
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Decarboxylation of allylic esters of 4-carboxypyrimidines in toluene at 111 degreesC in the presence of a Pd(O) catalyst, gives a mixture of a 4-alkenylpyrimidine and a pyrimidine unsubstituted in the 4-position. If the decarboxylation is carried out in the presence of benzaldehyde, then benzaldehyde is added to the 4-position. Decarboxylation of 4-carboxypyrimidines in the presence of different electrophiles, results in incorporation of the electrophile into the 4-position together with a pyrimidine unsubstituted in the 4-position. Use of microwave irradiation enhances the rate of the decarboxylations.
引用
收藏
页码:219 / 224
页数:6
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