Symmetry in the synthesis of the A-ring of a vitamin D hybrid analogue with significant transactivation activity: A combinatorial sequence of regioselective propiolate-ene, catalytic enantioselective epoxidation and carbonyl-ene cyclization reactions

被引：38

作者：

Mikami, K

Osawa, A

Isaka, A

Sawa, E

Shimizu, M

Terada, M

Kubodera, N

Nakagawa, K

Tsugawa, N

Okano, T

机构：

[1] Tokyo Inst Technol, Dept Chem Technol, Tokyo 152, Japan

[2] Chugai Pharmaceut Co Ltd, Chuo Ku, Tokyo 104, Japan

[3] Kobe Pharmaceut Univ, Dept Hyg Sci, Higashinada Ku, Kobe 658, Hyogo, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(98)00272-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The combination of the regioselective propiolate-ene reaction, catalytic enantioselective epoxidation and catalytic enantioselective carbonyl-ene cyclization completes the synthesis of the A ring of the hybrid 19-nor-22-era D-3 analogue (1), which shows the significant activity in transactivation. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3359 / 3362

页数：4

共 49 条

[1]

[Anonymous], 1992, Org. Synth

[2]

Baba S., 1994, B SOC CHIM FR, V131, P525

[3] STRUCTURE-FUNCTION-RELATIONSHIPS IN THE VITAMIN-D ENDOCRINE SYSTEM [J].