Microbial toxins and the glycosylation of Rho family GTPases

被引：53

作者：

Busch, C ^{[1
]}

Aktories, K ^{[1
]}

机构：

[1] Univ Freiburg, Inst Expt & Klin Pharmakol & Toxikol, D-79104 Freiburg, Germany

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2000年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0959-440X(00)00126-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Large clostridial cytotoxins act on cells by glycosylating low molecular mass GTPases using nucleotide-sugars as the sugar donor. These toxins are important virulence factors in human and animal diseases, but are also valuable cell biology tools. Recent findings shed some light on their mode of action and provide new insights into the structure/activity relationship of these bacterial toxins.

引用

页码：528 / 535

页数：8

共 72 条

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