Microwave-assisted multi-component synthesis of fused 3-aminoimidazoles

被引：114

作者：

Ireland, SM ^{[1
]}

Tye, H ^{[1
]}

Whittaker, M ^{[1
]}

机构：

[1] Evotec OAI, Abingdon OX14 4SD, Oxon, England

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 23期

关键词：

D O I：

10.1016/S0040-4039(03)00941-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of fused 3-aminoimidazoles have been synthesised by a microwave assisted Ugi three-component Coupling (3cc) reaction catalysed by scandium triflate in methanol as solvent. Yields of 33-93% have been achieved after just 10 mill of microwave irradiation using a simple one-stage procedure. The methodology described is suitable for the rapid and efficient synthesis of a range of fused heterocycles of pharmacological interest. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：4369 / 4371

页数：3

共 7 条

[1]

Bienaymé H, 1998, ANGEW CHEM INT EDIT, V37, P2234, DOI 10.1002/(SICI)1521-3773(19980904)37:16<2234::AID-ANIE2234>3.0.CO

[2]

2-R

[3] Parallel synthesis of 3-aminoimidazo[1,2-a]pyridines and pyrazines by a new three-component condensation [J].