ROLE AND REGULATION OF RUNX2 IN OSTEOGENESIS

被引：551

作者：

Bruderer, M. ^{[1
]}

Richards, R. G. ^{[1
]}

Alini, M. ^{[1
]}

Stoddart, M. J. ^{[1
]}

机构：

[1] AO Res Inst Davos, CH-7270 Davos, Switzerland

来源：

EUROPEAN CELLS & MATERIALS | 2014年 / 28卷

关键词：

Stem cells; bone; osteogenesis; differentiation; transcription factor; RUNX2; BONE MORPHOGENETIC PROTEIN-2; TRANSCRIPTION FACTOR CBFA1; CORE-BINDING-FACTOR; OSTEOCALCIN GENE-EXPRESSION; GROWTH-FACTOR-BETA; OSTEOBLAST DIFFERENTIATION; CLEIDOCRANIAL DYSPLASIA; COLLAGENASE-3; PROMOTER; DEPENDENT ACTIVATION; HISTONE ACETYLATION;

D O I：

10.22203/eCM.v028a19

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its interactions within the osteoblast differentiation pathway are often overlooked. This review aims to summarise the knowledge of its regulation at the transcriptional, translational and post-translational level. In addition, the regulation of RUNX2 by factors commonly used during osteogenic studies will be discussed.

引用

收藏

页码：269 / 286

页数：18

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