Co-stimulation and selection for T-cell help for germinal centres: The role of CD28 and OX40

被引：73

作者：

Walker, LSK ^{[1
]}

Gulbranson-Judge, A ^{[1
]}

Flynn, S ^{[1
]}

Brocker, T ^{[1
]}

Lane, PJL ^{[1
]}

机构：

[1] Max Planck Inst Immunbiol, D-79108 Freiburg, Germany

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 07期

关键词：

D O I：

10.1016/S0167-5699(00)01636-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Given the importance of responding to infections with the right defensive strategy, much interest has focused on cytokine differentiation in CD4(+) T cells. However, relatively little is known of the logistics of T-cell help for B cells. Here, Lucy Walker and colleagues propose key roles for CD28 and OX40 in coordinating the selection, expansion and migration of CD4(+) T cells to B-cell follicles.

引用

页码：333 / 337

页数：5

共 36 条

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