Basic Science of Pulmonary Arterial Hypertension for Clinicians New Concepts and Experimental Therapies

被引:402
作者
Archer, Stephen L. [1 ]
Weir, E. Kenneth [2 ,3 ]
Wilkins, Martin R. [4 ]
机构
[1] Univ Chicago, Cardiol Sect, Chicago, IL 60637 USA
[2] VA Med Ctr, Minneapolis, MN USA
[3] Univ Minnesota, Minneapolis, MN USA
[4] Univ London Imperial Coll Sci Technol & Med, Dept Expt Med & Toxicol, London, England
基金
美国国家卫生研究院; 英国医学研究理事会;
关键词
BONE MORPHOGENETIC PROTEIN; SOLUBLE GUANYLATE-CYCLASE; NITRIC-OXIDE SYNTHASE; SMOOTH-MUSCLE-CELLS; ENDOTHELIAL PROGENITOR CELLS; PYRUVATE-DEHYDROGENASE KINASE; VASOACTIVE-INTESTINAL-PEPTIDE; CALCIUM-CHANNEL BLOCKERS; CAPACITATIVE CA2+ ENTRY; SEROTONIN TRANSPORTER;
D O I
10.1161/CIRCULATIONAHA.108.847707
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:2045 / U175
页数:27
相关论文
共 206 条
  • [1] Appetite-suppressant drugs and the risk of primary pulmonary hypertension
    Abenhaim, L
    Moride, Y
    Brenot, F
    Rich, S
    Benichou, J
    Kurz, X
    Higenbottam, T
    Oakley, C
    Wouters, E
    Aubier, M
    Simonneau, G
    Begaud, B
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (09) : 609 - 616
  • [2] Low-molecular-weight heparin inhibits hypoxic pulmonary hypertension and vascular remodeling in guinea pigs
    Al-Ansari, Essam
    Du, Hong-Kai
    Yu, Lunyin
    Ochoa, Cristhiaan D.
    Garg, Hari G.
    Quinn, Deborah A.
    Hales, Charles A.
    [J]. CHEST, 2007, 132 (06) : 1898 - 1905
  • [3] AMPK and metabolic adaptation by the heart to pressure overload
    Allard, Michael F.
    Parsons, Hannah L.
    Saeedi, Ramesh
    Wambolt, Richard B.
    Brownsey, Roger
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2007, 292 (01): : H140 - H148
  • [4] Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease
    Alp, NJ
    Channon, KM
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (03) : 413 - 420
  • [5] Nitric oxide deficiency in fenfluramine- and dexfenfluramine-induced pulmonary hypertension
    Archer, SL
    Djaballah, K
    Humbert, M
    Weir, EK
    Fartoukh, M
    DalL'Ava-Santucci, J
    Mercier, JC
    Simonneau, G
    Dinh-Xuan, AT
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 158 (04) : 1061 - 1067
  • [6] Preferential expression and function of voltage-gated, O2-sensitive K+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction -: Ionic diversity in smooth muscle cells
    Archer, SL
    Wu, XC
    Thébaud, B
    Nsair, A
    Bonnet, S
    Tyrrell, B
    McMurtry, MS
    Hashimoto, K
    Harry, G
    Michelakis, ED
    [J]. CIRCULATION RESEARCH, 2004, 95 (03) : 308 - 318
  • [7] ARCHER SL, 2001, AM J PHYSIOL-HEART C, V294, pH570
  • [8] Phosphodiesterase Type 5 Inhibitors for Pulmonary Arterial Hypertension.
    Archer, Stephen L.
    Michelakis, Evangelos D.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (19) : 1864 - 1871
  • [9] Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension
    Asosingh, Kewal
    Aldred, Micheala A.
    Vasanji, Arnit
    Drazba, Judith
    Sharp, Jacqueline
    Farver, Carol
    Comhair, Suzy A. A.
    Xu, Weiling
    Licina, Lauren
    Huang, Lan
    Anand-Apte, Bela
    Yoder, Mervin C.
    Tuder, Rubin M.
    Erzurum, Serpil C.
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2008, 172 (03) : 615 - 627
  • [10] Signal transduction by the TGF-β superfamily
    Attisano, L
    Wrana, JL
    [J]. SCIENCE, 2002, 296 (5573) : 1646 - 1647