Decreased apolipoprotein A5 is implicated in insulin resistance-related hypertriglyceridemia in obesity

被引：43

作者：

Huang, Xian-sheng ^{[1
]}

Zhao, Shui-Ping ^{[1
]}

Hu, Min ^{[1
]}

Bai, Lin ^{[1
]}

Zhang, Qian ^{[1
]}

Zhao, Wang ^{[1
]}

机构：

[1] Cent S Univ, Xiang Ya Hosp 2, Dept Cardiol, Changsha 410011, Hunan, Peoples R China

来源：

ATHEROSCLEROSIS | 2010年 / 210卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Apolipoprotein A5; Triglyceride; Insulin resistance; Obesity; Inflammation; GENE-ENVIRONMENT INTERACTIONS; NECROSIS-FACTOR-ALPHA; ADIPOSE-TISSUE; HEPG2; CELLS; TRIGLYCERIDES; SERUM; RATS; DEFICIENCY; METABOLISM; EXTRACTS;

D O I：

10.1016/j.atherosclerosis.2009.12.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hypertriglyceridemia is associated insulin resistance in obese people. Recently identified apolipoprotein A5 (apoA5) is involved in triglyceride (TG) metabolism. This study was to investigate the role of apoA5 in insulin resistance-related hypertriglyceridemia in obesity. 682 participants including 340 non-obese individuals and 342 obese individuals were recruited in this study. Plasma apoA5 levels were measured. The insulin resistance in participants was assessed by homeostasis model assessment of insulin resistance (HOMA-IR). An insulin resistant and hypertriglyceridemic rat model was established by high-fructose diet with obese Zucker rats as positive controls. Besides, two insulin resistant models in vitro were induced by insulin and tumor necrosis factor-alpha (TNF alpha) in HepG2 cells. Obese participants had lower plasma apoA5 levels. Plasma apoA5 levels were inversely correlated with TG, body mass index and HOMA-IR in humans. Furthermore, hepatic and plasma apoA5 reduced in fructose-fed rats whereas no significant changes of apoA5 were observed in obese Zucker rats. In addition, treatment of HepG2 cells with insulin and TNF alpha decreased apoA5 expression and increased TG content. Thus, decreased apolipoprotein A5 is implicated in insulin resistance-related hypertriglyceridemia in obesity. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：563 / 568

页数：6

共 32 条

[1] Relationship of apolipoprotein A5 and apolipoprotein C3 levels to serum triglycerides in patients with type 2 diabetes [J].

Alborn, William E. ;

Prince, Melvin J. ;

Konrad, Robert J. .

CLINICA CHIMICA ACTA, 2007, 378 (1-2) :154-158

[2]

[Anonymous], 2000, WHO TECH REP SER, V894, P1

[3] ENZYMATIC DETERMINATION OF TRIGLYCERIDE, FREE-CHOLESTEROL, AND TOTAL CHOLESTEROL IN TISSUE LIPID EXTRACTS [J].

CARR, TP ;

ANDRESEN, CJ ;

RUDEL, LL .

CLINICAL BIOCHEMISTRY, 1993, 26 (01) :39-42

[4] Fructose feeding increases insulin resistance but not blood pressure in Sprague-Dawley rats [J].

D'Angelo, G ;

Elmarakby, AA ;

Pollock, DM ;

Stepp, DW .

HYPERTENSION, 2005, 46 (04) :806-811

[5] Plasma apolipoprotein A5 and triglycerides in type 2 diabetes [J].

Dallinga-Thie, G. M. ;

Van Tol, A. ;

Hattori, H. ;

Zee, L. C. Van Vark-Van der ;

Jansen, H. ;

Sijbrands, E. J. G. .

DIABETOLOGIA, 2006, 49 (07) :1505-1511

[6] Apolipoprotein AV does not contribute to hypertriglyceridaemia or triglyceride lowering by dietary fish oil and rosiglitazone in obese Zucker rats [J].

Dorfmeister, B ;

Brandlhofer, S ;

Schaap, FG ;

Hermann, M ;

Fürnsinn, C ;

Hagerty, BP ;

Stangl, H ;

Patsch, W ;

Strobl, W .

DIABETOLOGIA, 2006, 49 (06) :1324-1332

[7] Adipose tissue and atherosclerosis - Exploring the connection [J].

Fantuzzi, Giamila ;

Mazzone, Theodore .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2007, 27 (05) :996-1003

[8]

GENOUX A, 2003, ATHEROSCLEROSIS S4, V241

[9] Gene-environment interactions in the pathogenesis of type 2 diabetes and metabolism [J].

Grarup, Niels ;

Andersen, Gitte .

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2007, 10 (04) :420-426

[10] Long-term effects of tumor necrosis factor-α treatment on indulin signaling pathway in HepG2 cells and HepG2 cells overexpressing constitutively active Akt/PKB [J].

Gupta, Dhananjay ;

Varma, Shailly ;

Khandelwal, Ramji L. .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2007, 100 (03) :593-607

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